Correlation of psychotomimetic activity of phenethylamines and amphetamines with 1-octanol-water partition coefficients.

نویسندگان

  • C F Barfknecht
  • D E Nichols
چکیده

In an attempt to relate the hallucinogenic potencies in man of some biologically important amphetamines and phenethylamines, the 1-octanol-water partition coefficients for 11 amphetamines were determined. Using these values and published Hansch pi constants, the log P for 17 additional amines was estimated. It was found that lipophilicity, as measured by the log of the partition coefficient, may be a significant determinant of the level of hallucinogenic potency. The study also suggests that an ideal log P value for psychotomimetric activity in man may be from 2.89 to 3.72.

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عنوان ژورنال:
  • Journal of medicinal chemistry

دوره 18 2  شماره 

صفحات  -

تاریخ انتشار 1975